I’m in Physics Today: Web Watch!

A few days ago, I noticed several referrals to this weblog from Physics Today while browsing through the server access logs. Had a quick look, and didn’t see anything pointing to my weblog right away.

Looked again later on after seeing a few more referrals, and then I saw it in the Web Watch (subscriber sign-in required) section of the March issue! There it was, a link to my weblog! Web Watch is a little side column in Physics Today that highlights 2 or 3 interesting physics related websites. Have no idea how my weblog ended up there or even why since I haven’t really put much of any physics content here yet, aside from my Journal club postings. But still, very cool.

For those of you who don’t have access to the latest issue online and just can’t wait for it to show up in your local library, here it is.

http://blog.imabug.net
Eugene Mah, a medical physicist at the Medical University of South Carolina, keeps a daily weblog called IMABLOG. With a soupon of physics, Mah logs the minutiae of his daily life and reflects on the world in general.

Journal Club: Magnetic Field Induced DNA Strand Breaks in Brain Cells of the Rat

The researchers used a pair of homemade Helmholtz coils to produce magnetic fields and exposed rats to a 0.01 mT field (Earth’s magnetic field averages about 0.05 mT (50 µT) with significant regional variations) for 24 and 48 hours. The rats were sacrificed, the brains extracted and studied for single and double strand DNA breaks and apoptosis/necrosis using gel electrophoresis techniques.

Statistically significant differences were found in the number of DNA strand breaks between the exposed rats and control rats. Free radical production with NO and Fe+ ions were theorized to be the cause of the DNA strand breaks. Cell apoptosis was also found to increase following exposure. Experiments where the rats were administered free radical scavengers showed no difference between exposed and control rats. What remains to be seen, and what was not addressed in the paper is what kinds of health effects these breaks might have. This would probably be a difficult study to perform, since it would require studying a large number of rats over a long term to detect what is probably a very small effect.

Also not studied was the effect of DNA repair. The authors have clearly established free radical production as one mechanism of DNA damage in brain cells. But as is well known, cells are very good at repairing DNA damage. How much of the damaged cells would be repaired after 24 or 48 hours post-exposure? How significant would the loss of the cells be if the DNA could not be repaired and the cell died? What types of cells were most likely to incur damage? Since Fe+ free radicals were thought to be most likely involved, the authors felt that cells with higher Fe uptake would be more susceptible to damage. Authors also mentioned increased risk of neurodegenerative diseases, ALS, Alzheimer’s and Parkinson’s reported in previous literature due to occupational magnetic field exposure.

Journal Club: Impact of increased Al filtration on X-ray tube loading and image quality in diagnostic radiology

Ok, I haven’t finished writing up my thoughts on the last paper, but that’s just because I’ve been lazy. It was interesting paper, and I learned a few things. Still skeptical though. But more on that later.

This week’s article comes from Medical Physics and is titled “The impact of increased Al filtration on x-ray tube loading and image quality in diagnostic Radiology” by RH Behrman (Med Phys 30, 69-78 (2003)).

When I was an undergrad (way back in 1991), one of the projects I did (and the first one I did in Medical Physics) for my 4th year physics lab course was to study dose reduction to pediatric patients undergoing cardiac catheterization procedures. My lab partner and I looked at reducing radiation dose by adding a copper filter at the x-ray tube. So this paper was of particular interest to me. Added filtration significantly reduces low energy x-rays that don’t contribute to image formation, but then you need to compensate by boosting the x-ray technique.

Most fluoroscopy systems now come with automatic systems that add or remove filters of various types depending on the amount of radiation received at the receptor. Good for the patient, but harder on the generator and x-ray tube. I also suspect that the added filtration also leads to increased scatter exposure to the doctors performing the procedure. Since the added filter increases the effective energy of the x-ray beam, and Compton scatter increases with energy, there should be more scattered radiation This is one of the things I’ve been wanting to study for a while (one of the many research project ideas gathering dust in the back of my brain). Maybe I should find a way to get a summer student or something to work on this with me.

Abstract:

Previous work has shown that for nine common radiographic projections (AP abdomen, AP cervical spine, LAT cervical spine, PA chest, LAT chest, AP hip, AP lumbar spine, LAT lumber spine, and AP pelvis) increasing the total x-ray tube filtration from 2.5 mm Al equivalent (the regulatory minimum for general diagnostic radiology) to 4.0 mm Al equivalent, reduces the average effective dose and average skin entrance dose by 9% and 16%, respectively, using a 400 speed screen-film system.1 In this study, the effects of this filtration increase on x-ray tube loading and image quality were assessed. For the above projections and filtration increase, mean absolute and percentage increases in tube loading were 2.9 mAs and 15%, respectively, for a constant film density and fixed kVp. Tube current (mA) increases of 25% (a worst case) resulted in no statistically significant loss in focal spot resolution due to blooming for both large (1.2 mm) and small (0.6 mm) focal spot sizes, except at high mA low kVp techniques. The latter losses were below 10%, and when the image receptor blur was incorporated, the total system spatial resolution losses were on the order of one-quarter to one-half these values for typical clinical geometries. Radiographs of a contrast phantom taken with 2.5 and 4.0 mm total Al equivalent x-ray tube filtration were compared at 60, 70, 81, 90, 102, and 121 kVp. No statistically significant changes were observed with regard to (1) test object conspicuity as reported by three observers, (2) image contrast, as measured using a densitometer with a 3 mm aperture (±0.0017 OD, 95% confidence level), and (3) pixel value image noise, image contrast-to-noise ratios, and image signal-to-noise ratios, as measured using a scanning densitometer with a 12-bit acquisition depth and 85 µ pixel size (±2.5%, ±3.1%, and ±2.5%, 95% confidence levels, respectively). These results, combined with the linear no-threshold model for radiation risk and the ALARA principle, suggest that general radiography should be carried out using a minimum of 4.0 mm total Al equivalent filtration. ©2003 American Association of Physicists in Medicine.

Friday Five

What was…

1. …your first grade teacher’s name?
Mrs. Shamchuck. I even went to her retirement 12 or so years later.

2. …your favorite Saturday morning cartoon?
Superfriends

3. …the name of your very first best friend?
Derek

4. …your favorite breakfast cereal?
Honeycomb

5. …your favorite thing to do after school?
Go out and play.

To do: Learn CSS

I suppose one of these days, I shall have to get around to fixing that problem with the side bar where it spreads out at the bottom of the page for short entries. That means I’ll have to get around to learning CSS. Just another item on my List of Things To Do.
Maybe I’ll just do away with the side bar on the archive pages. Or maybe I’ll just make a shorter version of the sidebar to use on the archive pages. More things for my List.